I don't think anyone would ever be happy with a game based on a Bible story. If you take too many artistic liberties (which you'll have to, since the stories tend to be rather concise), you'll catch a lot of flak from literalists/fundamentalists for not sticking to canon, and if you don't, well then you get pretty short games with a rather predictable outcome.
Which is a shame, really, 'cause I've just started reading the Bible (gotta know what all the fuss is about, right?) and in Genesis alone there's plenty of material for a pretty badass game.
Like, Cain (the dude who killed his brother) was excommunicated from God's kingdom, but was worried he'd get his ass kicked for being a murderer. So God decreed that for every harm that would come to him, it would be dealt back sevenfold. After that, there's not much mention of him.
So combine that with earlier Genesis: Adam and Eve weren't kicked out of Eden for disobeying (their punishment was for Adam: having to work his ass off for his food, for Eve: serving man and a painful birth, and the snake: eternal animosity between its kind and mankind, and having to crawl around on his belly for eternity), they were kicked out to prevent them from finding the Tree of Life. For extra safety, he put a cherub on guard there with a frickin' FLAMING SWORD.
So how's this for a game: Cain, son of Adam and Eve, with God-given powers of seven-fold retribution, goes to look for the Tree of Life guarded by an angel with a burning sword, looking to become God's equal and get some frickin' respect.
AWESOME