Keep in mind the last time I saw a pokemon "anime" was Ash leaving the first area/land/island/whatever.
The last game I played was green, I think. It was pretty much the first red/blue but with updated graphics, the story was exactly the same.
Anyway, as far as the anime goes, get Ash to catch all the pokemon! The ************ wanted to catch them all but left the first area with about 10, you still got another 140 to go lil buddy! Another thing, he had all the badges from the first bit but Charizard was like "Imma do what I want!".
As for the games, leave them the fuck alone! These games are making Mario releases look sparse! Is the gameplay really that different? Get a diverse team, grind them to a respectable level, beat the elite 4, play multi player ...