I have gotten to play left 4 dead 2 this weekend, and I can say that it is definitely feels very different from the first game
1. Weapon selection, there are at least 2x the number of guns from the last game, and although they fall into the generic shotgun, machine gun, or other category, they all have a really fun and unique feel (AK47 and Magnum FTW!). And we cannot forget the addition of the melee weapons, there are few things more satisfying than getting to decapitate some zombies with a katana, machete, or electric guitar.
2. Campaign layout, in L4D, the stages of the levels were all 5 stages, with about the same distances between checkpoints, and very similar finales. In L4D2, some of the individual stages can last twice as long as usual ones do, some of the campaigns don't even have 5 stages, just 4 much longer ones (Especially the mall and the carnival). Also, in this one, you sometimes get little missions you have to do to complete the level, I really liked how the mall finale was set up and the last campaign in the city.
3. Zombies, the new zombies add a whole new challenge to the game. You will be all clustered together in a nice uniform group... then WHAM, a Spitter will come out of no where and acid you for a ton of damage. Chargers are also mad fun to play in versus mode and jockeys are a major pain to kill due to their size. My only complaint is that witches seem a lot easier to kill in this game than in the first one.
4. AI, the zombies are also a lot smarter this time around. They have strategies and know just how to pick out that one lagging player in the group with a well placed hunter or smoker. However, I am on and off when it comes to the human AI. Sometimes they are god-like players who snipe out a spitter from half a mile away, then there are the times where they are trying to knock the jockey off you with a melee weapon... and aiming at your feet.
All in all, it feels very different from the first game, and don't even get me started on the graphics.