ArmA2, I haven't played ArmA much, but the little I got to play was brilliant, nice to see some realistic FPSes out there.
Prototype, Intresting concept, seemed a bit like Assasins Creed in a modern enviroment + guns and strange powers.
Dawn of War 2, I'm not the greatest fan of the original, but the RPG-RTS concept, mixed with the CoH engine seems pirdy nice.
EVE Online: Apocrypha, There's nothing as yet another free expansion, exploration and modular ships seems neat :3
EVE Online: Yet-unnamed-winter-expansison, no idea what's going to be in it actually, but Walking in Stations is a pretty good bet.
I Am Alive, not much is known, but intresting concept, the fact that it's being developed by Ubisoft worries me slightly... But they have done a couple of good games in the psat (Splinter Cell, Rainbow Six, Silent Hunter etc)
There's probably more, but nothing I can come up with now..