Shepard's a jerk.
Doom is a distant prequel to Warhammer 40 000, and Doomguy is actually the Emperor.
Kharn the betrayer is a pretty swell guy, Eldrad however is a dick. (Well the second part is true)
Master Chief is a flat chested woman.
JC Denton have a nano-aug to make coffee.
http://argajag.deviantart.com/art/request-for-vokuts-COFFEUS-EX-168037678?q=favby%3Avokuts%2F6720085&qo=51 <-- that's me as a Nano-aug angent btw.
Gordon Freeman never speaks because he's an actual mute.
Ivy Valentine is a guy.
Shas'la Kais is an excellent cardplayer, and frequenly playes poker with Captain Ardias.
(these two are from the WH40k FPS Fire Warrior, wich is rather bad. One lone fire warrior kills a Chaos Dreadnought in melee. Wich is absurd)