BioShock Infinite, only if they fix the rather dull gameplay the first two BioShock games had. Don't get me wrong, the new setting looks wonderful, but I'm not playing through another BioShock game if it was as unfun to play as the first two. Everything was great about those games, except for the gameplay.
Mass Effect 3 as well. I don't really have many doubts about the game, all I want is a solid shooter and a satisfying conclusion to the trilogy, and I'll be happy. Anything else is just bonus.