I was nearly going to say Mass Effect 2 aswell, like many others.
But the story, to me anyway, made me feel like I was just visiting friends, giving them a ride in the Normandy to one single boss fight at the end.
I was nowhere near as moved by the story as I was by ME1.
Dragon Age: Origins; whether due to the voice actors perfomances or otherwise; did draw me into the story more. And by the end of my game, I actually started to feel somewhat 'concerned' about what actually happened in Ferelden.
But I think Left 4 Dead 1.
Bill dies FFS.
I'm pretty sure everyone cried when they found that out.
I did.
