I can't believe nobody has said anything about this, even when mentioning Johnny Depp!
Fear and Loathing in Las Vegas (1998)
A almost trippy drug movie that has some good acting, laugh out loud moments, and truly bizarre drug sequences and disturbing scenes. Don't take it seriously or expect some kind of deep revelation, but the only theme was to point out the overdosed consumerism during the 70's.
Besides, where can you get human reptiles in a blood orgy, using a flyswatter at invisible bats, and watch the Depp be stoned out of his mind on a ether binge?
This line will be in my head forever.
"Two bags of grass, seventy-five pellets of mescaline, five sheets of high powered blotter acid, a salt shaker half full of cocaine and a whole galaxy of multicolored uppers, downers, screamers, leaughers...Also a quart of tequilla, a quart of rum, a case of budweiser, a pint of raw ether, and two dozen amyls.
We didn't actually need all this for the trip, but once you get locked into a serious drug collection, the tendancy is to push it as far as possible. The only thing that worried me was the ether. There is nothing more depraved than a man in the depths of an ether binge. And I knew we'd get to that rotten stuff soon."