Ultratwinkie said:
In (original) fallout lore that would piss off a lot of people. Remember, Ghouls are not just normal humans. There are bits falling off, and muscle atrophy. Some ghouls are so crippled they can't even fire anything bigger than a handgun. A lot of ghouls cannot run very well. Its restrictive.
I've had the thought of playing as a ghoul myself, but I agree with this. It would cause way too many gameplay problems for the player.
Furthermore, most of the gameplay of Fallout3 and NV would be off limits to a ghoul character. It would be impossible to fool the NCR just by wearing their faction armor, and you wouldn't be able to just waltz into a town and start talking to people, since a lot of people would be prejudiced towards you.
Even though the choice of playing as a ghoul would be awesome, the game would probably just end up consisting of hanging out in some abandoned metrostation or sewer somewhere.