I'll buy it as long as it's not on Origin; InB4 OMFG DE ORIGIN HATERZZ!1!!!1, I don't really care about DRM or having it take up part of my hard drive. My problem would, however, stem from the fact that I'd have competition. I don't have Origin, but if it's anything like Steam (Which I doubt), there will probably be pop-ups and stuff like that, which I really don't need, because I'll probably be yelled at by my friends (OMG peer-pressure!) for using it.
And if there's multiplayer, I doubt some of my friends will download it, because they may think Origin is the root of all evil. If you won't be needing Origin, that works too, just as long as they don't lie about it like they did with BF3 on Steam.