All of Fallout 3, given decent-knowledge of other two games or a short-trip to the Vault Wiki. Power of the Atom stands out a lot.
Tenpenny wants to set off the bomb because he considers Megaton a blight in the landscape. A blight in the middle of the motherfucking wasteland filled with skeletons,ruins and raiders. WHAT THE FUCK IS WRONG WITH HIM!?
Simms asks you to disarm the bomb the moment you enter the city and Burke asks you to set it off first time you enter the bar. While I can understand Burke's actions, why the fuck would Simms ask a complete stranger to fuck around with something that can potentially lay waste to half of the wasteland?
Finally, given that the quest requires a whooping 35 Demolitons skill something a base character can reach by eating Mentats, how come on one else bothers to disarm the bomb? I'm pretty sure Jericho and Moriarty could easily do it, if Moira refuses after further persuading.
Also there's Harry Potter. No only does a giant evil wizard takeover all of UK and no one notices, apparently three underage wizards can hide and outrun the entire Ministry of Magic and the said evil wizard for a couple of months despite the fact only one of them has ever shown any decent magical ability and even said person couldn't sustain such disguise for more than a couple of days. Then there's the case of guns which not only would work in Harry Potter universe but would also be pretty damn efficient at killing wizards seeing how the latter wouldn't be able to execute a deflective spell before the bullet reached their brains.
