Only when they annoy me, or when the game doesn't allow me to do what i would do, if it was real life.
See, when my friend and I saw ****** at the end of ME2, we went:GiantSpiderGoat said:Do you respond to what Characters say in the game or do you scream something out at the screen when you see a cool event.
I often do this. I respond to what characters say even though my character may be replying.
Like in my latest case at the end of Mass effect 2 I screamed outDam it. I knew Sky net was behind all this. When you see the human type reaper being built.