I usually have to be at the suicidal point of being stuck on something before I look at a guide these days, although I used them more when I was little. When I use a guide, I try to look only at the exact thing I'm stuck on and figure out the rest on my own.
I also try to do side quests and find hidden shit on my own after my first runthrough/doing the story, although I will look up things if they're really obscure.
My only real exception to this has been Fallout New Vegas, where I've looked up the quest I didn't know existed which I just failed by shooting some guy in the head. This unfortunately happens quite a lot.