Hasn't there been some heavy clues that the new Fallout will be in New England? With them taking photographs there and whatnot?
If anyone wins, NCR wins. The Legion started off bad with the slavery and whatnot. But not even the fact their lands are the safest in the U.S. can change the fact the fact they're sexist, homophobic, and child soldier using bad guys. I still have no clue why I aided them the first time.
House... doesn't know what to do with power. He isn't even a contender for me. He managed to defend one city from burning, I don't know how he could do so for an entire wasteland.
Independent would be my second choice, just to see what New Vegas could become.
NCR is the best for several reasons. First, of all the factions, they're the first I would consider good. Though members of the NCR may be bad and some of them may be high ranking, the ideals are good. They seem to be accepting of almost everything and reward hard work. With Hoover Damn under their control, they could easily spread their nation further. If Fallout 4 wanted to continue the NCR/Legion story, I would want the NCR to win, form an alliance with The Brotherhood of Steel, and have the game be them trying to take the East Coast over.