My liking of Family Guy ended when my "getting drunk is cool" phase ended (about 2006). Basically, I'd only ever really watched the show while drinking and found it hilarious. Once I stopped doing that, I realized that it was worth little more than the occasional chuckle. Other animated comedies that have been running way longer manage to keep things fresh and interesting. Family Guy is just a bunch of stupid, annoying characters that I can't even begin to relate to. There's nothing "human" about them. Homer Simpson is a good character because he actually has a real, human side to him. He may be an idiot, but he loves his wife more than anything, and they actually show it. Peter is just a fat, stupid tool. Stewie is really just evil/gay. The most interesting character in the show is a dog. Sure, the characters might say something funny here and there, or something I agree with on occasion... but the show completely lacks any substance beyond its stock, forced "random" humor and obvious, cliched observational comedy.
tl;dr: Nay.