I literally lol'd when I saw this thread.
As others have said, this show hasn't affected my life in the slightest. Sure I enjoy it and the whole Brony phenomena has been rather interesting--not to mention my McDonalds ponies underneath Alduin next to my bed--but it hasn't been some crazy life changing show that makes me a better person every time I watch an episode.
You know what has changed my life? Ghost in the Shell.
Before I watched any GitS, I didn't think all that much about humanity, existence, sentience, and what separates humans from non-humans (especially machines). After watching GitS (especially Innocence) there was a period of my life when I didn't think I was alive, when I didn't think my life was any different from a coffee machine. That was a very interesting period of my life where the only thing that got me through it, was watching more GitS. I'm pretty sure the cute little Tachikoma saved my soul, because if it weren't for those cute little mecha-spiders, I'd still be wondering what the point of living is.
MLP:FiM - be friendly and accepting < GitS - question your existence and humanity
And like Daymaterasu said, there are just a lot more shows out there that are better, Firefly being a notable one.