There's a reason I almost never buy new games anymore unless I can get them for under $10 (Steam, GOG, etc). But for physical copies on handhelds or consoles.. I refuse to buy a game for more than $30, even that's pushing it. I'll buy it a year or two later, as I have done for a very long time now.
Then again, if Used Game sales dry up, I can always play any of the 500+ games I have in backlog. If I can't get the game at a huge discount, I just don't fucking need it. A rare exception would be something that I know already had a shaky release and needs to do well.. such as Phoenix Wright or possibly Adventure Time.
There's a reason I only have a handful of games for my Xbox 360, and why I stopped buying Wii games even though I saw plenty worth being interested in. I'll probably never get to play ICO because GameStop won't stop asking 30 gods-damned dollars for a game that's scratched up in a fucking sleeve! Nevermind the exorbitant prices for it online when the friggin' PS3 version is out there. It's no surprise people are pirating more games these days, too.
Publishers are demanding too much as it is, and development costs are rising too high for games to make the proper amount in sales. If a game NEEDS to sell over 5 million copies to break even, somebody needs to realize that they're making the games WRONG.