They are similar, but also very different. For story, I think inFamous wins, as the good/evil choices add variety, as well as change the gameplay and story. However, for combat, Prototype takes the lead. This leads to another point about combat. Infamous has a variety of powers for both melee and ranged attacks, but electricity doesn't allow any guns or vehicles. Prototype only has one ranged attack and only accounts for military vehicles. As I said, infamous has far better storyline and characters, but Prototype has better combat. Another point, infamous will have a sequel, but there are no plans for a prototype 2