Hello escapist.
I just finished replaying PROTOTYPE again when I looked back on the games I've played, movies I've watched, and books I've read that involve some sort of deadly virus. And I thought to myself, "which is worst?" So to the point. What virus or disease from any form of storytelling, be it a game, a book, a movie, a comic strip, a zoetrope, anything, is the worst of the worst?
Personally my vote goes either to the Blacklight Virus varient DX 1118 A.
Or the Forced Eveloution Virus.
So escapist, what disease is the worst of the worst?
EDIT: regarding the flood.
The reason I didnt include them as a choice is that they arent a viral or bacterial agent, they are an organism that uses what eveloution has given them, they are not a disease.
I just finished replaying PROTOTYPE again when I looked back on the games I've played, movies I've watched, and books I've read that involve some sort of deadly virus. And I thought to myself, "which is worst?" So to the point. What virus or disease from any form of storytelling, be it a game, a book, a movie, a comic strip, a zoetrope, anything, is the worst of the worst?
Personally my vote goes either to the Blacklight Virus varient DX 1118 A.
Engineered to copy the best biological traits from a host, and instill them in the carrier, when introduced into a host has a delayed kill ratio of 99.999%. When no host is avaliable, the disease can manifest itself in an artifical body several times bigger and more powerful than any human.
Human host after 2 weeks of infection
Hunter, the viruses created body (note this is not to scale, a hunter is several feet over an human.)
Human host after 2 weeks of infection

Hunter, the viruses created body (note this is not to scale, a hunter is several feet over an human.)

Or the Forced Eveloution Virus.
Designed by the encalve goverment in the fallout games to create super soilders capable of incredable feats of strenght and endurance, the forced eveloution virus causes increased growth in both muscle mass and physical reserves. More often than not, the searing pain involved in the process severs the infecteds grap on their mind causing amnesia of their past life and decrease intelligence. However certain host have managed to retain their minds and their wits. When introduced into human hosts, the outcome is almost always a super mutant.
When introduced into lizards, the result is a deathclaw

When introduced into lizards, the result is a deathclaw

So escapist, what disease is the worst of the worst?
EDIT: regarding the flood.
The ancient force that wiped out the almight race of forerunners. Even the most minute contact with them result in total compramise of the nervouse system, giving the parasite absolute control over the host body. The only surefire way to destroy the flood in any number is the total destruction of their food source (Sentient creatures with a large enough biomass to infest). This prompted the galaxy wide suicide pill of the halo rings.
Basic form
They also have the ability to generate a body that can change into differnet forms for different kinds of approach to an attack.
'Tank' flood
Controlled by the single largest flood organism, Gravemind.
What began as a simple flood spore, consumed enough sentient minds to grow sentient itself, and assumed control over all flood.
Basic form

They also have the ability to generate a body that can change into differnet forms for different kinds of approach to an attack.
'Tank' flood

Controlled by the single largest flood organism, Gravemind.

What began as a simple flood spore, consumed enough sentient minds to grow sentient itself, and assumed control over all flood.
The reason I didnt include them as a choice is that they arent a viral or bacterial agent, they are an organism that uses what eveloution has given them, they are not a disease.