Ulysses, but not in a, "I'll never look at life in the same way," deal, more of a, "Fuck you and your bullshit, James Joyce," way. The same can more or less be said about the Tale of Genji and the Sound and the Fury by Faulkner.
The opposite can be said about Faulkner's Light in August and As I Lay Dying. Also, Rushdie's Satanic Verses (not all that Satanic really), Dostoevsky's Brothers Karamazov, Nietzsche's Thus Spoke Zarathustra, Shusaku Endo's Silence, Mishima's the Sea of Fertility tetralogy, and I suppose I should give a shout out to Henderson's novels Native and Augusta Locke, just because and a bucket/several bookcases I don't feel like listing.