Nintendo might get some thumbs up from the accessibility community if there was a southpaw option. I don't know how the DS firmware works, but being able to mirror all the buttons (ABXY <-> DPad) at the OS level would mean left handed players wouldn't be disadvantaged and developers unaffected.
This seems like a fun project actually. I should see if there's DS documentation.
This seems like a fun project actually. I should see if there's DS documentation.