I have to go with SW:TOR first (assuming it makes a November release), followed very closely by Uncharted 3. Love the universe and characters in both. I guess I'd put Skyrim in third.
I used to love the TES series (Arena, Daggerfall, Morrowind), but for me, Oblivion was a let-down. I finished the main (and very repetitive) campaign in less than 10 hours, and that's a major problem with an RPG in my book, considering I play them for characters and story. The sandbox element of the TES series that some people love doesn't do much for me though - nowadays I get bored quickly when there's no story or objective to work on. Just trying to get more points/gold/fame/uber items/etc. holds no appeal. I've been playing RPGs since the very first Ultima on an Apple II, so I've done it all a million times before, better technology/graphics/gameplay mechanics notwithstanding. At least some of the mods gave me more play out of Oblivion.
None of the other games holds any interest for me at all.