Yes, assuming it's not a direct sequel to the first trilogy. Shepard's story is over and done with, I want a new set of characters, a new protagonist, a new epic story. Having things carry over from game to game is nice on one hand, but also a ton of baggage on the other. And boy, is there a lot of baggage by this point. I very much enjoy the ME universe; it's a solid Sci-Fi setting that actually puts some thought into the actual workings of the futuristic technology (granted, less and less as the trilogy progressed, with the third game essentially being about Space Magic).
A genre shift might not be a bad thing either. You can do pretty much anything - go full on RPG, go full on shooter/action, go strategy/tactics, etc. But even if they stick to the existing formula, I wouldn't have a problem with that, as long as they can deliver on the narrative and the characters...