Wesker is not really, dead, comes back and creates a NEW new supervirus to infect the world for whatever reason. The setting will be in space, fighting moon zombies who are actually reanimated Ganados that were the offspring of lickers and careful attention will be made to avoid the touchy subject of murdering space zombies. Along the way, there will be at least 15 plot twists, all of them easily forseen, in the first chapter alone (Spoiler: Wesker is Chris's father and Ada Wong is Leon's long lost stepsister).
Oh yeah, and you will have TWO AI partners to help you, only everyone has 3 inventory spaces and your friends will attempt to kill everything with their space knife instead of their upgraded shotgun. The only command you can issue them are ATTACK and FOLLOW ME, occasionly with the HELP OVER ABRITRARY OBSTICLE command.
...so yeah, resi 6 sounds like a crackerjack idea