Morrowind is VASTLY different from Oblivion. Argonians and Kajhit cannot wear footwear,nor full faced helmets,blocking is all luck(although on a successful block,ALL damage is stopped),in fact,all of combat,magic,and most of stealth is luck. Vampirism (to my knowledge) is MUCH rarer,just as easy to get rid of in the early stages,MUCH HARDER to get rid of when terminal,and all vampires in the game are extremely powerful,clad in extremely tough armour,and spreading death (and sometimes undeath) to those around them using Glass/Ebony/Deadric weapons,there's a second disease class to handle,known as "Blight",creature diseases are FAR more frequent,anything better than Steel MUST be found in very specific places. You can get a deadric weapon early in the game by finding an ebony mine near Balamora and reporting it to a certain Dunmer House Leader in Vivec (St.Olms district,top floor,haunted manor,pick a lvl 50 lock). Speaking of deadra,you need an enchanted and/or Silver/Dwarven/Glass/Ebony/Deadric weapon to harm them. You need very specific souls(Golden Saints)to make constnt effect enchantments(on the plus side,you can put more than one effect and all that on a WEAPON to boot). You'll be hoofing it A LOT unless you decide to be a Mysticism buff for the teleportation spells.
Although this all may seem negative,I find it all positive. It makes the game difficult and challenging,which provides an overall more rewarding experience when you do something or find something like the Deadric Face of God (one of three Deadric helmets,best helmet stat wise in-game). Also,did I mention the alteration spell that allows you to FLY? I had ENDLESS fun with that spell.
