That One Boss

[Stabby McRunfast]

Henry or Jeane from No More Heroes

 

[drisky]

G.L.A.D.O.S would be one, Sho Minamoto from World Ends With You would be another.

 

[ReinofFire]

Bongo Bongo from OoT, The Lion colossus (forgot his number, somewhere around 13 or 14)and Izuel from Diablo II. (sorry if I can't spell in spanish).

 

[DRTJR]

Lavos (Chrono trigger)

 

[LostinOriginality]

Nine Toes from Borderlands. Great experience before the game started to suck.

 

[Artanith]

Any Colossus from well...Shadow of the Colossus.

 

[jboking]

Metal Gear Solid 4 - The REX vs RAY fight is just incredibly fun and epic. The final fist fight with Liquid Ocelot was pretty good too.

 

[AnimeMan127]

Dr. Peace(NMH), Captain Blue(VJ), and Phantom(DMC).

 

[Solid Snake2053]

This is a really tough choice to make. I'll pick from my favorite games.

In terms of challenge, any one of those Green Golem bosses from the Mega Man games tend to be extremely difficult especially in Megaman X 5, which may not be a great game in comparison to other Mega Man games but damn, is that boss difficult.

Because it is one of my favorite games of all time, the ending fight with Kefka, while not challenging (if you have leveled up and do not place limits on yourself like I do) was very fun to play. You finally get to take on that madman!

But my favorite fight of all time, hands down is:

Metal Gear Solid 4, versus Liquid Ocelot. The final scene leading up to this last battle was shot beautifully and the emotions of the actors coupled with the tension between the characters created the perfect final fight that I had been waiting for since Metal Gear Solid 2.

 

[BlumiereBleck]

Axel (second fight as Roxas) Larxene (last fight with her) and Xemnas in kh2

 

[FNG Nemesis]

The final boss in Castle Crashers, I thought I killed him so many times... Then he changes forms again. lol

 

[RN7]

The Guardian from Epic Battle Fantasy 2. Because that music is bomb as hell.

Most of the final fantasy bosses were cool too.

 

[Brad Shepard]

the last bosses in Final Fantasy 8 right when you think your done, BOOM! another form
The last boss in Mass Effect 2 those who fought him know what im talking about
The Boss from MGS3
and every boss in SoTC

 

[HotShooter]

Just about every boss in Metal Gear Solid 4 (especially the beauty battles). The Rex vs. Ray fight was probably the best of them, though.

 

[Normalgamer]

Last boss of ME2, I just love the music and atmosphere.

 

[Toar]

Manhunt... the two final bosses Piggsy and that director Starkwether. It was refreshing to actually murder your boss in a way that is both greusome and entertaining... Then again, I'm a little off my rocker...

 

[Beardon65]

GIANT ENEMY CRAB!!!

Sorry, had to get that out of my system. Seeing as just about all of the games I play don't really have bosses, I'd have to go with Shadow of the Colosus. The entire game was a boss battle if you think about it.

 

[lyfeindeyth]

The first boss in Castle Crashers

HELLYES! That fight is sooo much fun! Grindtastic

 

[Krythe]

Depends on what consitutes "One"ness:

Best in Terms of Novelty:

Spoiler

http://i84.photobucket.com/albums/k22/Spartan_Jackal/My%20Memes/ChaoticEvil1.jpg

Best in Terms of Most Emotionally Charged: This one's kinda tricky...
Probably Roxas vs. Axel #2 in KH2. (Before he decided to become an hero.)

Best in Terms of Voice Acting: Ansem from KH1. Billy Zane. No further description needed.

Wierd that none of my favorite bosses come from my favorite games, but eh.