Ok this isn't really a repeated one line, but it annoys me every time I play the level.
In uncharted 2, on the second level where you rob the museum place, when you come out onto the roof, Nathan Drake says "There's the tower". Now, he says this, right infront of the MASSIVE tower, that fills up the whole screen basically. Flynn replies with "We're almost there now" to which Nathan Drake replies "Thanks for the update captain obvious" IT ANNOYS ME SO MUCH. HE JUST POINTED OUT THE MASSIVE TOWER IN FRONT OF HIM AND HE SAYS THAT TO FLYNN.