That one weapon..

[The_ModeRazor]

The AK-47.
When you absolutely, positively need to kill every ************ in the room, accept no substitutes.
I know it usually isn't the best automatic weapon available in video games, but it's always effective, and goddamn, is it sexy. And iconic.
And any automatic sniper rifles, so even if I miss the first headshot, I can easily try again without losing time. Dragunov is a pretty good example.

 

[Reaper69lol]

The BFG. C'mon it even has a cool name!

The Big Fucking Gun, ^ going to have agree on that. There is always something very special about big green plasma destroying everything in its path

 

[Guffe]

I'm having difficulties choosing between a big freaking revolver or my Love Gun!!!

 

[RIOgreatescapist]

Taking the fact that it could very well be the only game I'm clearing at the moment, Call of Juarez's volcano gun.

 

[GundamSentinel]

The SVD Dragunov. So vereh sexy.

Very fond of this gun when playing S.T.A.L.K.E.R. Clear Sky. <3

Spoiler

I love the Dragunov in any game, but for me Max Payne 2 sticks out. It just worked so smooth combined with bullet time.

 

[Adecristo]

Halo 1 Pistol = Semi-automatic Sniper Rifle, with shitload of ammo.
This.

 

[Galimor]

The gravity beam emitter from the Blame manga. It kicks ass.

EDIT: Basically, it's the weapon of choice when you not only want to make someone disappear, you use it to make everything in a 1,5 meter radius and 70 km length disappear of the face of the earth.

 

[Sir Kemper]

Cheap, Reliable, and effective.

I know there is a just like your mom joke in there somewhere but I won't stoop to that level...

But your mom did last night.

;P

 

[bubba145]

its not real yet but the modern version of the Lemat. a pistol with a shotgun attatchment

 

[SaberXIII]

The unnecessarily large and totally impractical katana used by Setsuna in the Negima series

 

[Mr Companion]

Bare hands in fallout 3, nothing makes a deathclaw more useless than constant paralysis and crippling.

 

[Fallen-Angel Risen-Demon]

Keyblade.
Just keyblade.
Forget Sora just... just... just keyblade.

 

[The Procrastinated End]

Frostmourne because everyone needs someone interesting to talk to.

 

[holographicman]

a rock.

the first weapon ever used by mankind

 

[Sacman]

Cheap, Reliable, and effective.

I know there is a just like your mom joke in there somewhere but I won't stoop to that level...

But your mom did last night.

;P

LOL...

 

[Supraliminal]

The PS20 from Deus Ex

A single shot plasma-based stealth weapon.
That pretty much sums it up.