Hoo boy, I guess I'd better admit it: I read Ctrl+Alt+Del. And by that, of course, I mean the past tense of "read (kind of annoying that the past and present tenses of that word are spelled the same)."
For me, the comic had its moments. In the very beginning, he made some decent self-and-not-self-referential humor, which was especially funny to me since I read a few of the comics being referenced in those early strips (that and I just have a weakness for fourth-wall jokes). Also, some of his standalone gag strips elicited a few chuckles; sure, quite a few of them were beaten to the punch (or possibly rip-offs, but I don't want to jump to conclusions), but some were still admittedly funny.
However, Yahtzee has already explained exactly the point at which even fans of the comic were suddenly let down: the shift to a "serious" story paradigm. What was this author thinking? The comic series was supposed to be built around comedy, or at least the attempt at comedy. As such, the characters themselves were pretty much one-dimensional foils that should have done nothing more than bounce jokes off of eachother. While characters in a comedy don't have to be so one-dimensional, and generally shouldn't, it worked sometimes for this comic.
Then, of course, the whole "pregnancy followed by miscarriage" story arc happened. The biggest flaw in logic when postulating this story was that any reader in their right mind would take a character like Ethan seriously. The guy is an obsessive man-child whose love of video games is only slightly eclipsed by his love of boobies. He was a ludicrous character through and through. And now you suddenly want me to sympathize with his pain? I'd like to point out right now that my sister also used to read the comic. Ever since the miscarriage, she hasn't so much as looked at the site.
At least just before the point of no return, the guy was still trying to squeeze in a joke at the end of the strip. The miscarriage comic itself? No punchline whatsoever. Then again, that might have been for the better; any joke made about miscarriage is in bad taste. This pattern of strips with no joke has actually continued on after that arc. These three strips, for instance: other than the "How many of those little bottles of booze are you legally allowed to serve us?" line (which is a really weak line, anyway), nothing in those strips can be considered a punchline by any stretch of the imagination. You know you're comedy strip sucks when you have to make an entirely different series of comics running parallel to the first called "Sillies."
Another complaint about these latest strips in particular: How the heck are they getting married? Weren't they married before or something? And even if they weren't and I'm just having a memory lapse, how can they just have a wedding in Jamaica on a whim? Could you imagine trying to tell that to any of your potential wedding guests? "Yeah, hey, uh, sorry for the short notice, but we're on a plane headed for Jamaica to get married right now, and if you could come, that would be really great. Bye!" Even if this was supposed to take place a few weeks or months after the plane strip, there is no indication of such a time skip. That third strip has to be one of the most confusing, stupid, and, most importantly, unfunny comic strips I have ever had the displeasure of viewing.
The short version: What little goodness this strip had has been destroyed by the author's stupid new direction.