The funniest "Let's Play" that you've ever seen?

[TheFederation]

Ah, my favourite Let's Play?
Let's see, can anybody here say...

"Hello once again, Audience"

i don't care if only you and me understands that, HELL YEAH

 

[Cheesus333]

Not really a "lets play" but is still one of the funniest freakouts I have ever heard while playing a game. Laughed to tears.

Oh God, I remember that XD

I laughed so hard I had to think of a new metaphor to adequately relay the extent and intensity of my laughter.

But I couldn't, 'cus I was laughing too hard.

 

[Zero=Interrupt]

The Let's Play of Drakengaard is a freaking hilarious read.

 

[H0ncho]

Sengoku rance:

http://www.rpgcodex.net/phpBB/viewtopic.php?t=37634

NSFW!!!

Takes a while to really get going but is a goldmine of lulz

 

[Argtee]

All of jefmajor's Let's plays are really funny. (in my opinion)
Even if I don't like the game, I still find it fun to watch him play it!

 

[GiantRaven]

Not one mention of Chip & Ironicus [www.chipandironicus.com]? I've never seen Let's Players who are as funny, informative and downright professional as these guys.