Well, apart from the usual deaths in the family, fathers leaving and girlfriends breaking up, I do have one unusal one for you:
After about 4 years in an acting and art course in my school (it even counts as a "main subject", meaning lots of lessons per week), I was still not very much liked. I was normally the only boy, the only exceptions always left the school as fast as they had joined it. So, after 4 years barely concealed disdain, we were coming to an end, and what an end it was! Our first actual play, written by us, was to be shown and I had written quite a lot of it and had a main part. One of my classmates was very nervous. So I cracked a joke. She was the only one who heard it, and it cheered her up. So she looked at me, smiled, and said: "Hey, you're actually really funny!"
Now, you might ask why that was so crushing. It was because in that moment, I saw in her face that for the very first time, one of the girls in that class actually looked at me like a human being. I was never one to get weighed down by the scorn of others, but in that moment, I felt 4 years of ignorance and scorn crushing down on my shoulders, and only now had at least one of them noticed me for something other than being a weirdo.
On the other hand, the play as a blast. It was pure comedy, and everyone laughed and loved it. One of the rare opportunities to actually perform a bit of physical comedy in a subtle way. It was fun to play, and fun to see everyone laughing and smiling.