Dead Rising 2, fighting the insane C.U.R.E protestor that had a single shard of glass and kept leaping and teleporting around like a ninja in the stalls.
Let's see, I have: Sledgehammers, Lightsabers, Knives, nail gloves, fire gloves, a shotgun and good ol' fashioned OJ. Him: shard of glass. Alright I got thHOLY SHIT HE'S GOT A HUGE HEALTH BAR OMG DID HE JUST LEAP INTO THE STALLS WHERE IS H*stab*.
The most one-sided fight in my favor would be me being kritzed as a demoman against their whole team, sans sentry guns.