Keeping in mind that no fewer than half a dozen games will call themselves "Game of the Year" when all is said and done, Skyrim, Uncharted 3 and Arkham City are all locks.
I'm more excited for Saints Row 3, but I doubt anyone's going to be calling that GOTY.
Zelda:SS and Dark Souls will also get a lot of attention.
Call of Duty isn't going to win any GOTY awards, but it will become the highest selling game ever.
Though if it doesn't, I wonder if Activision will blow up the franchise like they did Guitar Hero.