Always choose the most dangerous option in any scenario...chances are you'll get something good for your bravery/stupidity (too many games to name here).
You genuinely can make someone's head explode with a well placed shot (many shooters and the Resi series)
In the event of a zombie outbreak, one or two rugged, intellegent, young and otherwise sexy college students/cops will easily be capable of eliminating the hordes of the undead and few biological super soldiers while the army will be wiped out to a single survivor (Resident Evil).
Most poets of the 19th and 20th century were also locksmiths, the fashion of the time happened to be random colorful objects like emblems and coins. (Resident Evil again)
Gods are very much like us humans (God of War series).
Chicks dig protaganists (Mass Effect, Resident Evil 4, Dead Rising, Gears of War...just kidding, Corpse Killer for those of you old enough to remember, Splatterhouse, Mario series...the list goes on).
Bigger muscles = greater allergy to lead (think about it, Marcus Fenix from GoW is reduced to gorey chunks after a few rounds while Gordon Freeman or Matthew Kane, from Quake 4, can take a preverbial arse kicking before needing a quick breather).
When in space, the medical lab/deck is the last place you want to visit besides the basement (Alien vs. Predator(2)/Alien Trilogy)