Joe 'Red' Hartsock gets hospitalized just past the halfway mark in the game when a building collapses onto him and 3 others. Matt Baker (who had his face mutilated in said collapse), his best friend and the player character in the first and third game (you play as Red in the second game), is asked to tell the good news.
Why's it 'good'? Red had been wanting to go home to his wife (he's the only married character in the game; ironically his ring finger gets shot off in the second game) and his daughter, who he has never seen (his wife was still pregnant when he got drafted). He's going home, but not in the way you really want him to. He's paralyzed from the waist down. And I can't help but think he's still a lucky one.
The cutscene, if you do not plan on playing the game (but seriously. Buy it, play it, love it). The scene I'm talking about starts at about 2:00, ends at 5:00, the rest isn't all that relevant and pretty much requires you to play the game to really understand. The music freaking tears me up.
http://www.youtube.com/watch?v=0nqddHyvdYc