I wouldn't say cry, because I haven't done that in three years [I think]...
But I was pretty surprised that I got that almost misty-eyed feeling at the end of Blood Diamond.
It has personal meaning to me, long story, and it hit me pretty hard.
EDIT: Also, when my grandmother died a few months back. It wasn't so much her death that hit me, [she lives in Africa and I'd only seen her twice, that I remember] but that I felt like a shitty granddaughter for not having seen her more. And I felt awful for my grandfather. And for my dad.