Shenmue 2 was probably the ending that affected me the most. For those who aren't enlightened, after four discs of puzzling, running, investigating and fighting your way through Hong Kong's underworld and the gang-run streets of Kowloon, bumping into a huge variety of colourful characters along the way, the entire fourth disc starts with you arriving alone in the middle of the Chinese countryside. And for the entire rest of the disc, you're just walking through a forest.
I won't say much more, because I don't want to spoil it. All I'll say is, it's the most unusually submersive couple hours of gaming I've ever experienced.