Spyro The Dragon - Oh for the love of God, pleeeeeaaaase let it die. The original trilogy was awesome, but without Insomniac for the development and Stewart Copeland for the music... It's just an empty husk.
COD, Medal Of Honor, Battlefield, etc. Not ALL of them, but there are just too many 'modern warfare' shooters these days, most of them sprung forth from long running series. Time to weed out a few.
Many many many things by Nintendo. ESPECIALLY all those spin-off games Nintendo whores its characters out to. I mean, I can't blame the company, it pretty much feeds on loyal fanboyism like a vampire (REAL vampire, not Ed Cullen) does on blood, so KA-CHING goes the register. And I've always compared Nintendo strict G-ratings to the "keep it G/PG"-system of Hollywood: it's all about the cash.
And to all those who list Final Fantasy: sorry, but no.
At least Square-Enix still has the freakin' cojones to change the formula for each game, as opposed to, let's say, Nintendo (lookin' at you, Pokémon). Sure, not every formula works equally well, but at least they didn't milk the materia system for all it's worth - like so many others would have done. (Just for the record: I hated FF XIII, FF X-2's only redeeming factor was the combat system, FF VIII had the most paradoxal magic-system ever, FF XII had a sucky story and online FF's just don't interest me).