I recently finished paying off my Mass Effect 3 CE pre-order, but there are plenty of other games that I'm looking forward to this year.
X:Com Enemy Unknown: I liked the original when I bought it off Steam last year, but the clunky U.I. stopped me from really getting into it. That minor quibble looks to be fixed by the geniuses at Firaxis in their amazing looking re-imagining.
Kingdoms of Amalur: Go play the demo, you'll see why.
Bioshock Infinite: One of the best parts about gaming is the culture around it. It's the social interactions that arise from even a single player game like Skyrim, where I and a friend IRL or a stranger on the web can spend forever talking about all the cool quests we've embarked on.
Bioshock Infinite; with it's promise of a deep, affecting story, unique setting, and commentary on politics looks to be a game that will be talked about for a long time. And I personally want to be one of the people doing the talking.