I was already beaten to the punch about the Pixar moments, damn
Though if noises count that aren't words, the ending to Human Centipede is creepy and so depressing. The ending of the movie is in the spoiler, so if you want to be suprised, I would suggest not even glancing at it
But for those who don't read it, it's just the sense that the entire movie gave you, the image of the Human Centipede and everything, it's actions, it's depressing and creepy at the same time. Let me tell you, never going to watch that movie again...it was that good at it's job 
Though if noises count that aren't words, the ending to Human Centipede is creepy and so depressing. The ending of the movie is in the spoiler, so if you want to be suprised, I would suggest not even glancing at it
The girl in the middle, the surgeon, everyone except this one girl in the middle of the "centipede" is dead, and she's stuck unable to move, crying a muffled cry as the camera pans over the house and soft music fills in as the screen fades into credits