Memes are like any other joke - once told repeatedly, and too much, it gets old and people get fucking sick of it. Most of the more obscure ones are pretty funny, but stuff like "over 9000" and the whole concept of "the game" (which was actually clever, but then it got really fucking annoying) are just not that amusing anymore, especially when your real life friends constantly bring up said things.
But everything else seems to be used in moderation, and as I don't hang out on 4chan very often I don't really get sick of stuff as long as it's not something that would cross over into real life. Once it crosses over into real life, it bugs me just as much as teenage girls when they say "lol" instead of just laughing - it's something that belongs on the internet, not in real life.
But fuck, it's better than "your mom" jokes.