In the first game, I used Liara and Wrex/Garrus pretty much exclusively, depending on whether or not there was anything that needed to be hacked. I took Liara and Garrus to Ilos, and they are going to be my default team in the third game. It just seems right, my woman on my left and my homeboy on my right
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In ME2, though, it was usually Garrus and Mordin, though it would change depending on which characters made the most sense for the mission. For instance, Tali came along on Legion's loyalty mission, since we were killing geth and she would enjoy that. Also, I brought Tali and Garrus with me in the final battle, since they had been with me since the beginning. My Shepard trusted them the most, and wouldn't want to fight a giant Reaper fetus alongside anyone else.
Basically, I like to play the game in a way that "meshes" with the plot.
In ME2, though, it was usually Garrus and Mordin, though it would change depending on which characters made the most sense for the mission. For instance, Tali came along on Legion's loyalty mission, since we were killing geth and she would enjoy that. Also, I brought Tali and Garrus with me in the final battle, since they had been with me since the beginning. My Shepard trusted them the most, and wouldn't want to fight a giant Reaper fetus alongside anyone else.
Basically, I like to play the game in a way that "meshes" with the plot.