Things Invented in Pittsburgh, Pennsylvania.
First Big Mac - 1967
Created by Jim Delligatti at his Uniontown McDonald's, the Big Mac debuted and was test marketed in three other Pittsburgh-area McDonald's restaurants in 1967. By 1968 it was a mainstay on McDonald's menus throughout the country.
First Polio Vaccine - March 26, 1953
The polio vaccine was developed by Dr. Jonas E. Salk, a 38-year-old University of Pittsburgh researcher and professor.
The First Internet Emoticon - 1982
The Smiley

was the first Internet emoticon, created by Carnegie Mellon University computer scientist Scott Fahlman.
First Retractable Dome - September 1961
Pittsburgh's Civic Arena boasts the world's first auditorium with a retractable roof.