From a gameplay standpoint I think t would be cool to see a city like Detroit or DC. Cities that don't necessarily have Huge Skylines and are mostly suburbs but offer up great storylines. With DC you've got the whole "City of Government" thing, and with Detroit you have the fact that for a while it was near death, the history of crime (seriously, everyone talks about Al Capone and the Chicago gangs with the booze. Where do you think he got it from? Suppliers off the Michigan-Canadian border), and the current Border Town (Windsor). Plus it could be nice to show off the entire Metro Area and Windsor to people not native in the Midwest. Hell you might even be able to do Cleveland if you tried. And that's just another modern day story, no telling what you could do if it's set in the late 70's/early 80's