The Scrin, because they fuck your world up with a crystal that eats stuff up and makes it more of itself, which also makes them more powerful when they invade, something they only do once the "ichor" once they fuck your world up enough to make the ground itself kerplode, and even then they have flying razors that come and shred your armies and a super weapon that warps you into the depths of space, and that's only if you survive the legions of tank things and scarab legions.