Blind Sight said:
Ok, so up until that point the game was largely critical of Andrew Ryan's philosophy, which is based off Ayn Rand's Objectivism and rational egoism. Throughout the first half of the game Ryan's philosophy is seen as somewhat native, especially with Fontaine attempting to destablize his power base.
However, as Ryan is staring down his assassin he says a simple line: "A man chooses, a slave obeys." This is a fundamental element of Objectivism, that a strong individual chooses his role, while a weak one obeys the commands of others
It's more than that. Ryan stands against his assassin as every bit of a Objectivist he's been made to be, choosing to face his death, well, like a man, with every connotation of that phrase intended. But in saying that a man chooses, a slave obeys, guess which one you are? Jack's been ordered to do all of these things, and obeyed, but so have you as the player. How many games have you played where you did all of the things that you were asked? Man or slave, which were you being?
That one scene neatly critiques one of the central paradigms of video game design, where you do what you're told. There may be a narrative, objectives, or choices of how you wish to complete your quests or missions, but ultimately your choice is only to do them, or not. If not, you lose, or you can't continue playing. At every step, when someone has asked you in the game to complete a task, you've done it, probably without much hesitation, because if not, you'd have to stop playing. In a sense, it wouldn't make a difference whether Jack was brainwashed or not: you'd still do everything the game asked of you to keep going.