You get one weapon....

[Drundy]

Athena's Blades and the old fashioned pistol.

 

[Alkestes]

Horatio's sunglasses. And that would be all I'd need.

 

[rstank77]

charizard.

 

[IrrelevantTangent]

Hmm. Good question. I think I'd go with either two Covenant Plasma Rifles, or a Collector Particle Beam. The former is a deadly combination while the latter slices and dices everything with a pulse and everything without. God, I loved that weapon when playing ME 2. Best. Heavy weapon. Ever.

 

[Drakulla]

I would choose the "Mug Of Doom". Its a giant bear stein that never runs out of ale and I would get drunk and club everything that got in my way. Because whoever hold the "Mug of Doom" is unstoppable.

 

[Captain Schpack]

I'd take a lightsaber, a Model 1887 shotgun or Chuck Norris

 

[PyroZombie]

A hunter-style double barrel shotgun. I figure that if i go out I'm going out then i'm going out with a man's gun, either that or a fire ax.

 

[esperandote]

The haduken from megaman

 

[EpicPanda]

I change my mind.

The giant ball from Katamari Damacy.

Everything gets stuck to it, so why not?

 

[Doc Cannon]

Super Metroid's Hyper Beam. Not only it is a one hit kill on everything but the Motherbrain, but it also makes you invincible.

 

[jultub]

Impact, if it even counts as a weapon (I'm pretty sure it's sapient, so it might be a little doubtable).

Otherwise I'd go for a catapult that catapults catapults, where the second catapult catapults shuriken.

 

[Latinidiot]

pffft let's see......
infinite ammo lancer.
I don't reaally like GoW, but a gun/chainsaw sounds perfect.
you know what, screw that, I'm going with Kratos' chainblades, provided i have the skill and strength to use 'em

 

[kidigus]

The HL2 super gravity cannon.
I would kill for a game like that.

 

[The DSM]

The cannon from Serious Sam.

Or the cain from ME2, im want to kill them all at once, if I dont im screwed.

 

[Daffy F]

Does the portal gun count?

 

[drane10]

I'd either go with the Heavy Arms Gundam (with infinite ammo, that's Hell's worse nightmare!) or Terra's Keyblade so I can unlock anything I need (gun lockers, food places, banks, etc.), fly around in vehicle mode(the flying motorcycle-thing looks badass), and use as a giant f***ing cannon!

 

[SpireOfFire]

Thompson 1928 submachine gun with a drum magazine and infinite ammo.

 

[Greeboz]

Planet Cracker

 

[Evil the White]

Sasha with unlimited ammo. That'll teach em.