Duke Nukem; Time to Kill
Pretty much anything the Duke has to say, but I'll narrow it down to a few like "Bless me, father, for I WILL sin.", "Where's Doc Brown when ya need 'im?", and "COOOME GET SOOOME!!!".
Final Fantasy 5
Several cases of Galuf starting to remember things and then, when pressed for more information, he puts us in a facevault situation when he goes "Can't remember for the live of me.".
Destroy All Humans! 2
Crypto: "You realize the player has already gone out for a snack by now, doncha'?"
And now, just to throw the Mass Effect guy for a loop, let's take some from Evil Dead: A Fistful of Boomstick.
Ash: "You're probably wondering what a handsome devil like me is doing in a place like this with you, right?"
Ash: "When you've just emptied two barrels of a shotgun into the head of your favorite bartender it's a pretty good bet that happy hour's over."
Ash: "Boomstick: $199.99, Shells: 39.99, Zombies heads blowing off: priceless."
Ash: "We've secretly replaced this Deadite's brain with a chainsaw blade. But be quiet. Let's see if he notices."
Heh heh heh heh...