Well, I was in the Army and was qualified to use a variety of weapon systems. In games I tend to prefer rifles and machine guns (or flamethrowers, if present). In every day life I fence, so I suppose I could probably kill most people I meet in a sword duel but those don't happen often these days (thus why most people would suck at them).
On the occasion's I've been in an honest to god fist fight, I tend to favor getting in very close and going for soft spots (groin, neck etc). I'm a pretty small guy so I generally feel completely justified punching someone in the neck. Plus, up close it's harder for bigger guys to leverage their mass and strength. My fights rarely went well though - generally speaking I'd end up looking like hell-on-toast when someone breaks the things up. On the other side of things I've never had to fight someone twice, for what that's worth.
On the occasion's I've been in an honest to god fist fight, I tend to favor getting in very close and going for soft spots (groin, neck etc). I'm a pretty small guy so I generally feel completely justified punching someone in the neck. Plus, up close it's harder for bigger guys to leverage their mass and strength. My fights rarely went well though - generally speaking I'd end up looking like hell-on-toast when someone breaks the things up. On the other side of things I've never had to fight someone twice, for what that's worth.