I know a lot of folks will be hoping that due to Obsidian developing it, it will be closer to the originals than F3 was.
Personally I would like to see:
A different game engine to F3, it's cliched but I think Unreal 3 could do good things with a nuclear dystopia
The ability to dress your character in seperate clothing items unlike in Fallout 3: Wasteland of the Onesies
VATS (but with a seperate hitbox for the genitals... deathclaw penis crippled, try chasing me now asshole)
Personally I would like to see:
A different game engine to F3, it's cliched but I think Unreal 3 could do good things with a nuclear dystopia
The ability to dress your character in seperate clothing items unlike in Fallout 3: Wasteland of the Onesies
VATS (but with a seperate hitbox for the genitals... deathclaw penis crippled, try chasing me now asshole)